Clonality and timing of relapsing colorectal cancer metastasis revealed through whole-genome single-cell sequencing

J. Alves, S. Prado-López, L. Tomás, M. Valecha, N. Estévez-Gómez, P. Alvariño, Dominik Geissel, D. Modest, I. Sauer, J. Pratschke, N. Raschzok, C. Sers, S. Mamlouk, D. Posada

Cancer Letters, vol. 543, 2022

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors

T. Simon, P. Riemer, A. Jarosch, K. Detjen, A. Di Domenico, Felix Bormann, Andrea Menne, S. Khouja, Nanna Monjé, L. Childs, D. Lenze, U. Leser, F. Roßner, M. Morkel, N. Blüthgen, M. Pavel, D. Horst, D. Capper, I. Marinoni, A. Perren, S. Mamlouk, C. Sers

Genome Medicine, 2022

Negative hyperselection for mutations associated with anti-EGFR antibody resistance in RAS wildtype metastatic colorectal cancer (mCRC): Evaluation of the PANAMA trial (AIO-KRK-0212, maintenance therapy with 5-FU, folinic acid (FU/FA) with or without panitumumab).

Andreas Kind, D. Modest, C. Sers, S. Mamlouk, M. Karthaus, S. Fruehauf, U. Graeven, L. V. von Weikersthal, E. Goekkurt, A. Reinacher-Schick, S. Kasper, A. Kurreck, B. Hoppe, S. Held, V. Heinemann, David Horst, A. Jarosch, S. Stintzing, T. Trarbach, A. Stahler

Journal of Clinical Oncology, 2022

Serial Analysis of Gene Mutations and Gene Expression during First-Line Chemotherapy against Metastatic Colorectal Cancer: Identification of Potentially Actionable Targets within the Multicenter Prospective Biomarker Study REVEAL

J. Kumbrink, Lisa Bohlmann, S. Mamlouk, T. Redmer, Daniela Peilstöcker, Pan Li, S. Lorenzen, H. Algül, S. Kasper, D. Hempel, F. Kaiser, M. Michl, H. Bartsch, J. Neumann, F. Klauschen, M. von Bergwelt-Baildon, D. Modest, A. Stahler, S. Stintzing, A. Jung, T. Kirchner, R. Schäfer, V. Heinemann, J. Holch

Cancers, 2022

A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer

U. Pfohl, Jürgen Loskutov, S. Bashir, R. Kühn, Patrick Herter, M. Templin, S. Mamlouk, S. Belanov, M. Linnebacher, Florian Bürtin, Marcus Vetter, Christoph Reinhard, L. Wedeken, C. Regenbrecht

Cancers, 2022

Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer

F. Uhlitz, P. Bischoff, Stefan Peidli, A. Sieber, Alexandra Trinks, Mareen Lüthen, B. Obermayer, E. Blanc, Yana Ruchiy, Thomas Sell, S. Mamlouk, Roberto Arsiè, Tzu-Ting Wei, Kathleen Klotz-Noack, R. Schwarz, B. Sawitzki, C. Kamphues, D. Beule, M. Landthaler, C. Sers, D. Horst, N. Blüthgen, M. Morkel

EMBO Molecular Medicine, 2021

The majority of β-catenin mutations in colorectal cancer is homozygous

A. Arnold, Moritz Tronser, C. Sers, A. Ahadova, V. Endris, S. Mamlouk, D. Horst, M. Möbs, P. Bischoff, M. Kloor, H. Bläker

BMC Cancer, 2020

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe

Bastian Gastl, Kathleen Klotz-Noack, B. Klinger, S. Ispasanie, Krenoula Hani Fouad Salib, J. Zuber, S. Mamlouk, Natalie Bublitz, N. Blüthgen, D. Horst, M. Morkel, R. Schäfer, C. Sers

Cell Death and Disease, 2020

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression

S. Mamlouk, T. Simon, L. Tomás, D. Wedge, A. Arnold, Andrea Menne, D. Horst, D. Capper, M. Morkel, D. Posada, C. Sers, H. Bläker

BMC biology, 2020

DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer

P. Jurmeister, A. Schöler, A. Arnold, F. Klauschen, D. Lenze, M. Hummel, L. Schweizer, H. Bläker, B. Pfitzner, S. Mamlouk, C. Sers, C. Denkert, D. Stichel, Nikolaj Frost, D. Horst, M. Laffert, D. Capper

Modern Pathology, 2019

Robust in-silico identification of Cancer Cell Lines based on RNA and targeted DNA sequencing data

R. Otto, Jan-Niklas Rössler, C. Sers, S. Mamlouk, U. Leser

Scientific Reports, 2019

RED CELLS, IRON, AND ERYTHROPOIESIS HIF-1is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2-induced excessive erythropoiesis

K. Franke, Joanna Kalucka, S. Mamlouk, R. Singh, A. Muschter, A. Weidemann, Vasuprada Iyengar, Steffen Jahn, K. Wieczorek, K. Geiger, M. Muders, A. Sykes, D. Poitz, T. Ripich, T. Otto, S. Bergmann, G. Breier, G. Baretton, G. Fong, D. Greaves, S. Bornstein, T. Chavakis, J. Fandrey, M. Gassmann, B. Wielockx

2017

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

S. Mamlouk, L. Childs, D. Aust, D. Heim, F. Melching, Cristiano Oliveira, Thomas Wolf, P. Durek, Dirk Schumacher, H. Bläker, M. von Winterfeld, Bastian Gastl, Kerstin Möhr, Andrea Menne, Silke Zeugner, T. Redmer, D. Lenze, S. Tierling, M. Möbs, W. Weichert, G. Folprecht, E. Blanc, D. Beule, R. Schäfer, M. Morkel, F. Klauschen, U. Leser, C. Sers

Nature Communications, 2017

SoFIA: a data integration framework for annotating high-throughput datasets

L. Childs, S. Mamlouk, Jörgen Brandt, C. Sers, U. Leser

Bioinform., 2016

Loss of prolyl hydroxylase‐2 in myeloid cells and T‐lymphocytes impairs tumor development

S. Mamlouk, Joanna Kalucka, R. Singh, K. Franke, A. Muschter, Anika Langer, C. Jakob, M. Gassmann, G. Baretton, B. Wielockx

International Journal of Cancer, 2014

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

K. Franke, Joanna Kalucka, S. Mamlouk, R. Singh, A. Muschter, A. Weidemann, Vasuprada Iyengar, Steffen Jahn, K. Wieczorek, K. Geiger, M. Muders, A. Sykes, D. Poitz, T. Ripich, T. Otto, S. Bergmann, G. Breier, G. Baretton, G. Fong, D. Greaves, S. Bornstein, T. Chavakis, J. Fandrey, M. Gassmann, B. Wielockx

Blood, 2013

Hypoxia‐inducible factors as key regulators of tumor inflammation

S. Mamlouk, B. Wielockx

International Journal of Cancer, 2013